NFE2L2 and inflammatory skin disease: On the other hand, targeting AhR/Nrf2 is emerging as a novel treatment option for ambient pollutants that induce or exacerbate inflammatory skin diseases such as atopic dermatitis, psoriasis, etc. Therefore, AhR with downstream regulatory pathways would represent a crucial signaling system regulating the skin phenotype in a Yin-and-Yang fashion defined by the chemical nature of the activating factor and the cellular context.