As shown in Supplementary Figure S1A,B, the α-synuclein aggregate burden was higher (56 ± 19%, p = 0.0039, n = 3) in the Tg mouse model of PD compared to WT and agrees with the disease burden, and ARL6IP5 was decreased (71 ± 14%, p = 0.0002, n = 3) as compared to WT. This evidence concerns the gene SNCA and Parkinson disease.