IL6 and periodontitis: Thus, at the site of periodontitis, there is an imbalance of the cytokine and chemokine network characterized by increased levels of proinflammatory cytokines such as interleukin (IL)-1β, IL-6, and IL-12 and tumor necrosis factor (TNF)-α, and decreased levels of regulatory/anti-inflammatory cytokines such as IL-4, IL-1 receptor antagonist (RA), IL-10, and induced protein-10 [5,6].