BCR and chronic myelogenous leukemia, BCR-ABL1 positive: The Philadelphia chromosome (Ph) is the der(22) of the reciprocal translocation t(9;22)(q34;q11), which encodes the BCR-ABL, the oncogenic driver of chronic myeloid leukemia (CML) and 20–25% of cases of adult acute lymphatic leukemia (ALL) [19,20].