In the same paper, atopy was defined as a “personal or familial tendency to produce IgE” [36]; thus, the term proposed in the classification, “non-IgE-associated allergic AEDS”, would literally expand to “non-IgE-associated, i.e., non-atopic, allergic atopic, i.e., characterized by tendency to produce IgE, dermatitis/eczema syndrome”, a term implicating the absence and at the same time the presence of an association with IgE. This evidence concerns the gene IGHE and skin disorder.