ZFHX4 and neoplasm: Even so, our findings reinforced the high instability and heterogeneity of OS genomes and led to the identification of disrupted genes possibly linked to OS clinical features or development (DMD, KNL1, PTPRQ, TNFRSF11B, and ZFHX4), thus, contributing to the characterization of mechanisms likely involved in tumor development and progression that can be of interest for further investigation.