In contrast, a very recent meta-analysis of 23 studies (14 prospective and 9 retrospective case control) with 18 meta-analyzed biomarkers has found that survivors of LC presented higher levels of CRP, D-dimer, lactate dehydrogenase (LDH) and leukocytes than controls without LC; however, the effect sizes were small [172]. This evidence concerns the gene CRP and laryngotracheoesophageal cleft.