IL1RN and Behcet disease: In pigs with BD-induced RV dysfunction, tacrolimus prevented the increase in RV pro-inflammatory IL-6-to-IL-10 and IL-6R-to-IL-10R ratios and IL-6 signal transducer Gp130, IL-1 receptor antagonist IL-1RN, iNOS, and VCAM-1 gene expression, while the expression of IL-1β and HO-1 remained high in the RV (Figure 5).