GLP1R and type 2 diabetes mellitus: Given that T2DM is a multifactorial disease involving several hormones, their receptors, and subsequent intracellular activity, future therapeutic research must consider how the action of all these hormones interact synergistically in T2DM to produce the altered metabolic phenotype and also how treatments such as therapies based on GLP-1R activation can influence this hormonal synergism to produce a metabolic phenotype similar to that of a healthy individual.