TGFBR2 and cancer: Mechanistically, miR-211 was shown to regulate genes involved in melanoma, including KCNMA1, which has been linked to proliferation and metastasis in cancers, as well as insulin-like growth factor 2 (IGF2R) and transforming growth factor beta receptor II (TGFBR2), both important for facilitating the tumor suppressor function of TRPM1 [15].