PLG and infection: Hence, covering the surface of the bacteria with plasminogen and consequent activation of the system may facilitate the escape of bacteria from the initial site of infection and spreading in the host organism due to the ability to degrade ECM and basement membrane proteins, disintegrate tricellular tight junctions, and adhere and interact with endothelial and epithelial cells, as demonstrated so far for many different bacterial species and diverse infectious niches [42,49,50,51,52,53,54,55].