As IL-17 and IL-22 are elevated in mice exposed to the allergen, as well as in patients presenting symptoms of severe or moderate asthma, our study and our results suggest that IL-22 plays a pro-inflammatory function in airway allergic inflammation modulating it positively, as described by Besnard et al. [10], because IL-22 deficiency caused a reduction in eosinophils and lymphocytes in the BALF, IL-5 and IL-13 reduced inflammatory cell infiltrate in the airways and decreased mucus production by goblet cells in the lungs compared to WT group exposed to the allergen. This evidence concerns the gene IL13 and asthma.