IL5 and asthma: As IL-17 and IL-22 are elevated in mice exposed to the allergen, as well as in patients presenting symptoms of severe or moderate asthma, our study and our results suggest that IL-22 plays a pro-inflammatory function in airway allergic inflammation modulating it positively, as described by Besnard et al. [10], because IL-22 deficiency caused a reduction in eosinophils and lymphocytes in the BALF, IL-5 and IL-13 reduced inflammatory cell infiltrate in the airways and decreased mucus production by goblet cells in the lungs compared to WT group exposed to the allergen.