NLRP3 and Parkinson disease: A PC12 cellular line treated with MPP+ induced increases in the mRNA and protein levels of interleukin-6, IL-1β, and tumor necrosis factor-alpha [5]; likewise, MPP+ activates the NLRP3 inflammasome in microglia, and the NLRP3 inflammasome-activated microglia plays a pivotal role in the neurodegeneration associated with PD [6].