Significant improvements were reported in two Italian monocentric studies, which used clinical and ultrasound evaluation (at Careggi University Hospital in Florence and at Sapienza University of Rome in Rome) as early as at one month for joint scores and other clinometric scores [78,83], as well as in a Japanese registry, Tsurumai Biologics Communication Registry of RA patients (TBCR-RA), for DAS28-CRP change from baseline [74]. This evidence concerns the gene CRP and rheumatoid arthritis.