Previously reported overexpressed (<i>IL-10</i>, <i>MSR1</i>, <i>PHLDA1</i>, <i>SERPINB2</i>, and <i>CD86</i>) and underexpressed genes (<i>CHI3L1</i>, <i>CPA3</i>, <i>IL-8</i>, and <i>PI3</i>) in severe asthma were analyzed by RT-qPCR in peripheral blood mononuclear cells (PBMCs). This evidence concerns the gene SERPINB2 and asthma.