Strong indicators for a type-2 endotype in CRSwNP are late-onset asthma, tissue eosinophilia, blood eosinophils > 300 cells/μL, total serum IgE > 150 kU/L and the presence of S. aureus enterotoxin-specific IgE (SE-IgE). The gene discussed is IGHE; the disease is Increased total eosinophil count.