Significant differences in the serum profiles of pro-GN (5.27 vs. 11.35, <i>p</i> < 0.001), S100A12 (39.36 vs. 19.74, <i>p</i> < 0.001) and PTX3 (3197.05 vs. 1608.37, <i>p</i> < 0.001) were observed between pre-treatment patients with UC and healthy individuals. The gene discussed is PTX3; the disease is ganglioneuroma.