CD8A and neoplasm: After clustering the tissue density of CD8+ T cells with bacterial species enriched in LTS patients, a positive Spearman correlation was found between the two variables (p < 0.0001, p = 0.006, and p < 0.0001, respectively), suggesting that the diversity of the tumor microbiome and the presence of these three bacterial genera in the tumor may contribute to the anti-tumor immune response by promoting CD8+ T cell recruitment and activation.