Additionally, in Hershey, United States, three patients with biopsy-proven NASH had benefits thanks to a supervised 20-week telehealth-delivered exercise training program showing improvement through magnetic resonance imaging (MRI)-proton density fat fraction (PDFF) of measured liver fat, insulin resistance, body weight, and body fat in parallel with gains in physical fitness [76]. This evidence concerns the gene INS and metabolic dysfunction-associated steatohepatitis.