A higher preoperative WBC count and CRP (OR 1.9, <i>p</i> = 0.042, and OR 2.3, <i>p</i> = 0.019, respectively), as well as the presence of intraoperative perforation, necrosis or gangrene, perityphlitic abscess and peritonitis (OR 3.2, <i>p</i> = 0.001; OR 2.3, <i>p</i> = 0.023; OR 2.6, <i>p</i> = 0.006 and OR 2.0, <i>p</i> = 0.025, respectively) were identified as independent risk factors for conversion from the laparoscopic to the open approach. This evidence concerns the gene CRP and peritonitis.