Severe COVID-19 cases are characterized by an increase in pro-inflammatory cytokines plasma levels, especially interleukins IL-1β, IL-2, IL-6, IL-7, and IL-10 granulocyte-macrophage colony-stimulating factor (GM-CSF) and tumor necrosis factor-alpha (TNF-a) [6]. This evidence concerns the gene CSF2 and COVID-19.