In this study, the prospective EPIC adiponectin cohort showed no association with pancreas cancer risk; however, among never-smokers, higher circulating levels of adiponectin were associated with a reduction in pancreatic cancer risk, whereas smokers tended to have non-significantly increased pancreatic cancer risks, with raised adiponectin levels [99]. The gene discussed is ADIPOQ; the disease is familial pancreatic carcinoma.