ADIPOQ and neoplasm: We agree with the authors of [119,126] that in order to properly assess the role of leptin and adiponectin in PanNENs, it is necessary to take a closer look at the tumor microenvironment and the crosstalk between them and other hormones and proinflammatory cytokines, which foster carcinogenesis and cancer development and growth, in addition to assessing concentrations.