ADIPOQ and neoplasm: We failed to demonstrate an involvement of the changes in circulating adiponectin levels in the metastatic process, just as Colakoglu et al. and Warakomski et al., who, in their studies, found that there was no correlation between tumor size or clinical stage of disease and adiponectin [90,128], even though there were reports documenting elevations of adiponectin in metastasis tumors [98,104].