Similar results obtained by Gąsiorowska et al., together with Colakoglu et al. [90], present patients with pancreatic cancer as compared to controls had significantly lower plasma leptin [90,91], like other findings, which showed that patients with pancreatic cancer had lower circulating leptin levels compared to control patients [89] or to the overall population [92]. This evidence concerns the gene LEP and familial pancreatic carcinoma.