Consequently, in this study, we aimed to evaluate levels of leptin and adiponectin in PanNENs and healthy controls and explore the relationship between the concentrations of leptin, adiponectin, and the leptin–adiponectin ratio in PanNENs and tumor-related characteristics, such as the disease extent (presence of metastases), grade, or Ki-67. This evidence concerns the gene ADIPOQ and neoplasm.