We agree with the authors of [119,126] that in order to properly assess the role of leptin and adiponectin in PanNENs, it is necessary to take a closer look at the tumor microenvironment and the crosstalk between them and other hormones and proinflammatory cytokines, which foster carcinogenesis and cancer development and growth, in addition to assessing concentrations. This evidence concerns the gene LEP and neoplasm.