In the pivotal Medical Research Council (MRC) cytogenetic study on 5876 young adults with AML, including 705 cases of CBF leukemias [41], no significant survival impact of ACAs on OS was observed among these patients, consistent with other reports, possibly retaining the positive role of trisomy 22 in CBFB::MYH11 cases [20,55,56,57]. The gene discussed is CBFB; the disease is acute myeloid leukemia.