RUNX1 and acute myeloid leukemia: In addition, it is known that not all AML mutations have clinical utility for MRD monitoring, such as those found in age-related clonal hematopoiesis (e.g., DNMT3A, TET2, ASXL1) or in germline predisposition syndromes (e.g., DDX41, RUNX1, GATA2).