U2AF1 and acute myeloid leukemia: Given the extreme relevance of gene mutations and the strong association with ontogeny [27], according to the recent International Consensus Classification (ICC), the presence of ASXL1, BCOR, EZH2, RUNX1, SF3B1, SRSF2, STAG2, U2AF1, or ZRSR2 mutations defines the category of AML with myelodysplasia-related gene mutations and identifies a high-risk subgroup according to the ELN 2022 recommendations [38,39] (see below).