α-2,3 sialic-acid-bound SIGLEC15 enhances the production of C-C motif chemokine ligand (CCL)2, C-X-C motif chemokine (CXCL)2, and CXCL8 in TAMs, which not only exacerbates immune suppression but also accelerates tumor progression in gastric [117], esophageal [118], and bladder carcinomas [119]. The gene discussed is CCL2; the disease is neoplasm.