Moreover, the macrophage-derived proinflammatory chemokines, namely CC-chemokine ligand 20 (CCL20) and macrophage inflammatory protein-3α (MIP3α), all bind CC-chemokine receptor 6 (CCR6) on PDAC cells, leading to upregulated MMP-9 expression and tumor invasion [230,231,232,233] (Figure 2). This evidence concerns the gene CCL20 and neoplasm.