Furthermore, YY1 also promotes tumor angiogenesis by activating the transcription of VEGF while suppressing anti-angiogenic factors such as thrombospondin-1 (TSP-1), pigment epithelium-derived factor (PEDF), and tissue inhibitor of metalloproteinase 2 (TIMP-2) [103,133,134]. Here, TIMP2 is linked to neoplasm.