YY1 transcriptionally upregulates sentrin/SUMO-specific protease 1 (SENP1) and enhances the methylase activity of methyltransferase-like 3 (METTL3), leading to increased N6-Methyladenosine (m6A)-modification levels in MYC mRNA, which promotes the self-renewal of glioblastoma stem cells (GSCs) [158]. The gene discussed is YY1; the disease is glioblastoma.