YY1 modulates a mounting list of genes in different signaling pathways that regulate tumor development and progression, such as c-myc, c-fos, HER2, E1A, and p53 [18,19], and is involved in regulating various hallmarks of cancer, including sustained proliferative signaling, evading of programmed cell death, and deregulated metabolism. This evidence concerns the gene YY1 and neoplasm.