These include inhibiting mTOR1 and activating GCN2, resulting in the inhibition of T-effector cell function and apoptosis, suppressing NK cell proliferation and function, promoting the differentiation and activation of regulatory T (Treg) cells, tolerogenic dendritic cells (DCs), and myeloid-derived suppressor cells (MDSCs), as well as contributing to tumor neovascularization [32]. Here, EIF2AK4 is linked to neoplasm.