IFN-γ can induce the expression of more than 200 genes, including those involved in immune evasion by tumor cells, such as PD-L1, PD-L2, CTLA-4, CIITA, non-classical MHC class Ib antigens, IDO1, and CXCL12 [30]. This evidence concerns the gene CXCL12 and neoplasm.