WT1 and acute myeloid leukemia: Although one third of the leukemic blasts of the patients had compound heterozygous WT1 mutations (Table 1), the mRNA isoform expression profile in the mutated AML blasts still resembled the one detected in the WT1 wild-type leukemic cell lines and also in the 16 primary AML blasts with monoallelic WT1 mutations (Figure 2).