Somatic mutations in WT1 are detected in considerable number of patients with acute leukemia and often co-occur with other genetic alterations, for instance internal tandem duplications of the fms related receptor tyrosine kinase 3 (FLT3-ITD) gene or mutations in CCAAT/enhancer-binding protein alpha (CEBPA) in adult AML [19,20]. Here, WT1 is linked to acute myeloid leukemia.