The role of WT1 in the evolution of these tissues has proven to be crucial, since Wt1−/− animals do not survive the embryonic stage, and deletion of Wt1 in an inducible model of young adult mice led to fatal consequences such as severe glomerulosclerosis and impaired hematopoiesis with a diminished erythropoiesis [2,3]. This evidence concerns the gene WT1 and glomerulosclerosis.