SHARPIN controls the activities of NF-κΒ and PRMT5 [20,21], which regulate the production of ROS and are involved in both apoptotic and nonapoptotic cell death [51,52]; hence, we analyzed whether knockdown of SHARPIN inhibits the activities of NF-κΒ and PRMT5 in synovial sarcoma (Yamato) cells. The gene discussed is SHARPIN; the disease is synovial sarcoma.