F2 and acute promyelocytic leukemia: Consequently, it was previously assumed that the concomitant thrombotic and hemorrhagic phenotype of APL was akin to a sepsis-driven DIC; both present with pathologically low fibrinogen levels and an elevated prothrombin time (PT), elevated activated partial thromboplastin time (aPTT), and elevated levels of coagulation activation byproducts such as D-dimer [39].