LDHA and posterior cortical atrophy: LDHA protein levels were found to be significantly increased in high-Gleason primary PCa and in metastases from a large cohort of clinical specimens (881 cases, 203 non-neoplastic, 176 high-grade prostatic intraepithelial neoplasia, 480 PCa adenocarcinomas, 10 metastatic PCa, and 12 benign prostates from cystoprostectomies) [45].