Additionally, a Gleason score-dependent increase in lactate concentration of 0.37 ± 0.06 mM in benign tissue; 0.65 ± 0.12 mM in low-grade PCa Gleason score ≤ 3 + 4); and 1.5 ± 0.35 mM in high-grade PCa (Gleason score ≥ 4 + 3) was observed and correlated with higher LDHA mRNA levels [40]. This evidence concerns the gene LDHA and posterior cortical atrophy.