KLF9 suppresses both glioblastoma cell stemness and tumorigenicity by binding to the itga6’s promoter region and repressing its transcription [77], whereas Y-box-binding protein-1 (YB-1), an oncogenic transcription/translation factor, induces the expression of itga6 mRNA, leading to enhanced self-renewal, mammosphere growth, and resistance to paclitaxel treatment [54]. The gene discussed is ITGA6; the disease is glioblastoma.