The signal transduction downstream of ITGA6 has received little attention [15]; however, it is known that ITGA6 boosts the activation of PI3K/Akt and MEK/Erk, two key signaling pathways involved in tumor development, which leads to decreasing p53 levels and the promotion of angiogenesis, metastasis, and invasion [41,58]. Here, ITGA6 is linked to neoplasm.