Considering no KMT2A-rearranged cases in Yao et al.’s study of B-acute lymphoblastic leukemia specimens for evaluation of ITGA6 expression, it is possible that molecules other than this integrin are involved in B-acute lymphoblastic leukemia with KMT2A rearrangement infiltrating the CNS [59]. This evidence concerns the gene ITGA6 and acute lymphoblastic leukemia.