As there are pitfalls to finding an effective and safe therapy capable of inhibiting ITGA6 in vivo, and the functional blocking antibodies available may potentially cause important side effects if systemically administered because of its broad expression [73], another potential strategy to reduce the effects of ITGA6 may be reducing the movement of tumor cells toward pre-existing blood vessels, also called vessel cooption. This evidence concerns the gene ITGA6 and neoplasm.