In cancers, integrins interact with growth factors, growth factor receptors, cytokines, oncogenes, and enzymes [50,53,54,56,61,62] and then activate or amplify proliferation, invasion, and survival signaling pathways (e.g., MAPK/ERK, PI3K/AKT, Shc, and Rac) [54,56]. Here, AKT1 is linked to cancer.