ITGA6 and urinary bladder cancer: On the other hand, METTL3 promotes the translation of itga6 mRNA by upregulating the m6A modification of itga6 in the 3′UTR region [47], which induces the binding of YTHDF1/YTHDF3 to itga6 mRNA, boosting its protein translation and helping with bladder cancer development and relapse [8,42].