SigmaR1 regulates reactive oxygen species (ROS) via the ferroptosis component nuclear-erythroid 2-related factor 2 (NRF2) and was found to be both up-regulated and translocated away from the nucleus in hepatocellular carcinoma cell lines in response to the ferroptosis inducer sorafenib [27]. This evidence concerns the gene SIGMAR1 and hepatocellular carcinoma.