Since, in our study, the EMT-related biomarkers PRMT-1 and p120-catenin were found to be upregulated in the Osimertinib-resistant NSCLC cells, we performed a translational study with these biomarkers in the tumor samples of the NSCLC patients and correlated their expression with the smoking status of the patients. The gene discussed is CTNND1; the disease is non-small cell lung carcinoma.