We began our study by analyzing the expression of biomarkers PRMT-1, p120-catenin, and Kaiso factor in Osimertinib-resistant NSCLC cells with mutant EGFR (H1975 and H3255) and wild-type EGFR (H358 and H2170) and compared them to their parental cell lines. Here, PRMT1 is linked to non-small cell lung carcinoma.