In PCa, variants of this nature have been identified in mediators of DNA methylation (e.g., TET2, MBD1), histone acetylation (e.g., KAT6B, ARID4A), histone methylation (e.g., KMT2C, SETD2), as well as in chromatin remodelers (e.g., ARID1A, SMARCA1) [7,8,9,10,11]. Here, SMARCA1 is linked to posterior cortical atrophy.