SETD2 and posterior cortical atrophy: In PCa, variants of this nature have been identified in mediators of DNA methylation (e.g., TET2, MBD1), histone acetylation (e.g., KAT6B, ARID4A), histone methylation (e.g., KMT2C, SETD2), as well as in chromatin remodelers (e.g., ARID1A, SMARCA1) [7,8,9,10,11].