OPTN and glioblastoma: Additionally, the novel finding of PDGF regulating mitophagy (an autophagic process important for mitochondrial quality control) via methyltransferase-like 3 (METTL3) and optineurin (OPTN), specifically in GSCs, suggested a targetable PDGFR-METTL3-OPTN axis for GBM.