Single-cell profiling indicated that all isocitrate dehydrogenase (IDH)-mutant gliomas (astrocytomas and oligodendrogliomas), while differing in their tumor microenvironment (TME) and nonproliferating astrocytic and oligodendrocytic lineages, share a subpopulation of proliferative undifferentiated neural stem-like cells [91,92]. Here, IDH1 is linked to central nervous system cancer.