There are several mechanisms that contribute to cancer angiogenesis including the release of pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) from cancer cells, hypoxia, tumor-associated macrophages (TAMs), extracellular matrix remodeling, and tumor-associated endothelial cells (TECs) [65,67,68]. The gene discussed is VEGFA; the disease is neoplasm.