Investigation of its subunits WDR82, ASH2L DPY30 CXXC1, RBBP5, and WDR5 showed that WDR82 and WDR5 were significantly associated with WHO-grade malignancy in pediatric gliomas (Figure 1C, Figure 2 and Figure S1C). Here, CXXC1 is linked to central nervous system cancer.