A study showed 60% of mutant isocitrate dehydrogenase 1 (mIDH1)-glioma-bearing mice had complete tumor regression with reduction of exhausted T cells and generation of memory CD8+ T cells after receiving the combination of anti-PD-L1 antibody, 2-hydroxyglutarate (D-2HG) inhibition, irradiation and TMZ [26]. The gene discussed is CD8A; the disease is central nervous system cancer.