It is worth noting that current versions of asparaginase also have significant glutaminase activities, which may account for its unusual efficacy with asparagine synthetase (ASNS)-positive tumours, including those that are EBV-positive, e.g., natural killer/T cell lymphomas, where asparaginase is used as part of the SMILE regimen [48,49]. This evidence concerns the gene ASNS and neoplasm.