Figure 6A shows the GASP-1 overexpression in Stage 1 papillary carcinoma. As cancer progresses, more GASP-1 is overexpressed, and the aggregation of cytosolic GASP-1 forms powdery and fine granules. Figure 6D shows the GASP-1 expression in anaplastic carcinoma which is a highly invasive cancer. Coarse GASP-1 granules are abundantly present, and many are attached to plasma membranes. Previously, we have observed such coarse granules and their attachment to plasma membranes in highly metastatic breast cancer [23]. Here, GPRASP1 is linked to thyroid gland papillary carcinoma.