While GASP-1 overexpression starts in limited areas of the follicles in follicular adenoma producing localized overgrowth, GASP-1 expression is highly increased in follicles of both follicular carcinoma and papillary carcinoma, resulting in widespread uncontrolled overgrowth normally found in many cancers. Here, GPRASP1 is linked to thyroid gland papillary carcinoma.