While GASP-1 overexpression starts in limited areas of the follicles in follicular adenoma producing localized overgrowth, GASP-1 expression is highly increased in follicles of both follicular carcinoma and papillary carcinoma, resulting in widespread uncontrolled overgrowth normally found in many cancers. The gene discussed is GPRASP1; the disease is papillary carcinoma.