In the literature, a translocation to chromosome 12 is reported to be present in one-third of the cases of DAM, resulting in the aberrant expression of high mobility group A (HMGA) protein involved in DNA transcription [27,28]; in particular, rearrangements of the HMGA2 (12q14.3) locus have been identified in 8 chromosomal translocations involving HMG genes, which have been previously reported in various other mesenchymal neoplasms, including lipomas, liposarcomas, leiomyomas, and pulmonary hamartomas (Figure 2) [3,29,30]. This evidence concerns the gene HMGA2 and lipoma.