Some studies quantify the whole-body PSMA tumor volume (PSMA-TV) as the sum of all PSMA-avid lesions with a fixed threshold value of SUV ≥ 3, manually and semiautomatically excluding physiological uptake sites, to be used as a predictor of metastatic disease [16,17,18,19]. The gene discussed is FOLH1; the disease is neoplasm.