TFRC and brain glioma: Yue et al. [252] developed a transferrin receptor (TfR) monoclonal antibody (mAb) of rats (OX26) and CTX conjugated PEGylated liposome as a dual-targeting gene delivery system for GB which was found to significantly promote cell transfection, increase transportation of plasmid DNA across the BBB and target the brain glioma cells in vitro and in vivo.