Although some researchers have suggested that MMP-1 plays a more important role than MMP-2 in the migration, remodeling, and invasiveness of GB [142], it has been shown that high levels of MMP-2 play a more important role in the virulent progression of cancer through its contribution to three vital processes: angiogenesis, metastasis, and invasion [25,143,144]. The gene discussed is MMP2; the disease is cancer.