ClC-3 has been suggested to affect the invasion and migration of glioma cells by forming protein complexes with membrane type-I matrix metalloproteinase (MMP), MMP-2, tissue inhibitor of metalloprotein-2, and αvβ3 integrin, co-localizing with Ca2+-activated K+ channel to lipid raft domains of invadopodia [47,131]. Here, MMP2 is linked to central nervous system cancer.