The tumor suppressor DAB2IP (Disabled Homolog 2 Interacting Protein), also called AIP1 (ASK1 Interacting Protein), is a cytoplasmic Ras-GAP and adaptor protein that negatively modulates multiple oncogenic signaling pathways such as Ras-MAPK, PI3K-AKT, NF-kB, and GSK3β-beta catenin, thus affecting the reciprocal interaction between cancer cells and their microenvironment. The gene discussed is DAB2IP; the disease is cancer.