To further explore the mechanism that ONECUT2 regulated tumor progression, we analyzed the ChIP data of ONECUT2 from CistromeDB (http://cistrome.org/db, accessed on 25 February 2022) accession number: 104814) (GSM3136847) and found that ONECUT2-regulated genes were significantly enriched in the MAPK pathway. Here, ONECUT2 is linked to neoplasm.