The most common subgroup, PB-B, was distinguished by alternations in the miRNA-processing pathway genes DICER1, DROSHA, and DGCR8 and associated with an older age at diagnosis and longer PFS [67], reinforcing and elaborating upon previous studies establishing DICER1 alterations as important drivers in pineoblastoma [68,69]. This evidence concerns the gene DROSHA and pineoblastoma.