MET and RES inhibit PI3K/Akt signaling primarily by inhibiting the two PI3K phosphorylated subunits, the regulatory domain p85 and the catalytic domain p110, triggering a cascade of events that inhibits PIP2, PIP3, and PDK1, which are usually found to be upregulated in cancers as seen in Figure 1 [25,26,27,28,29]. Here, AKT1 is linked to cancer.