Cytoplasmic expression of TERT was already observed in non-clear cell and clear cell hepatocellular carcinoma [34,35], cervical cancer [36], prostate cancer [37], and urothelial carcinoma [33], suggesting possible telomere-independent functions of TERT under conditions of environmental stress such as hypoxia and oxidative stress. This evidence concerns the gene TERT and Familial prostate cancer.