We defined as PGCC those cells with size equal or larger than 50 μm and having cancer-like cytomorphological aspects (such as anisonucleosis, nuclear hyperchromatism, high nucleo-cytoplasmic ratio, atypical nucleoli, and atypical cell shape), also expressing tumor markers (TERT, PSMA, AMACR, vimentin and epithelial markers, etc.)detected by immunolabeling. This evidence concerns the gene AMACR and cancer.