A preclinical study has also shown that the anti-GD2 antibody 14G2a downregulates PI3K/Akt/mTOR signaling network in human NB cell lines (IMR-32, CHP-134, LA-N-1 cells), which is a critical pathway for growth and proliferation of NB cells [37]. The gene discussed is AKT1; the disease is neuroblastoma.