IL24 and cancer: We have shown that the adenovirus (Ad) vector expressing IL-24 (Ad.IL-24), IL-24 protein (generated from Ad.IL-24-infected cells), and adenovirus vector expressing nonsecretable IL-24 all display broad cancer-specific pro-apoptotic activity through induction of endoplasmic reticulum (ER) stress [17,39] (Figure 4).