IL24 and inflammatory bowel disease: IL-24 activates SOCS protein in the inflamed mucosa of patients with inflammatory bowel disease: IL-24 is induced in the mucosa by IL-1β in human colonic subepithelial myofibroblasts [24] through IL-24 mRNA stabilization via p38 MAPK activation once IL-24 is induced, and it increases the expression of membrane-bound mucins by inducing SOCS3 protein without affecting the proliferation or expression of proinflammatory cytokines such as IL-8, IL-6, or TNFα (Figure 2).